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    High Dose Flu Vaccine

    Does the higher dose vaccine produce a better immune response in adults 65 years and older?

    Data from clinical trials comparing Fluzone to Fluzone High-Dose among persons aged 65 years or older indicate that a stronger immune response (i.e. higher antibody levels) occurs after vaccination with Fluzone High-Dose. Whether or not the improved immune response leads to greater protection against influenza disease after vaccination is not yet known. An ongoing study designed to determine the effectiveness of Fluzone High-Dose in preventing illness from influenza compared to Fluzone is expected to be completed in 2012.

    Is Fluzone High-Dose safe?

    The safety profile of Fluzone High-Dose vaccine is similar to that of regular flu vaccines, although adverse events (which are also reported after regular flu vaccines) were reported more frequently after vaccination with Fluzone High-Dose. The most common adverse events experienced during clinical studies were mild and temporary and included pain, redness and swelling at the injection site and headache, muscle aches, fever and malaise. Most people had minimal or no adverse events after receiving the Fluzone High-Dose vaccine.

    Who can get this vaccine?

    Fluzone High-Dose is approved for use in people 65 years of age and older. As with all flu vaccines, Fluzone High-Dose is notrecommended for people with a severe allergy to chicken eggs, or people who have had a severe reaction to a flu vaccine in the past.

    Does CDC recommend one vaccine above another for people 65 and older?

    CDC and the Advisory Committee on Immunization Practices (ACIP) recommends flu vaccination as the first and most important step in protecting against the flu, however, neither CDC nor ACIP is expressing a preference of one vaccine over another at this time.

    How is the Fluzone High-Dose vaccine available?

    This vaccine is approved for marketing in 0.5 mL preservative-free, single dose, prefilled syringes.

    Where can I find more information about Fluzone High-Dose?

    More information about Fluzone High-Dose is available on the Food and Drug Administration (FDA) web site at:http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm112854.htmExternal Web Site Icon

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